Abernathy LM, Fountain MD, et al. Soy Isoflavones Promote Radioprotection of Normal Lung Tissue by Inhibition of Radiation-Induced Activation of Macrophages and Neutrophils. Journal of thoracic oncology. 2015;10(12):1703-12. PubMed PMID: 26709479.
Hillman GG, Singh-Gupta V, et al. Differential effect of soy isoflavones in enhancing high intensity radiotherapy and protecting lung tissue in a pre-clinical model of lung carcinoma. Radiotherapy and oncology. 2013;109(1):117-25. PubMed PMID: 24021346.
Mathews JD, Forsythe AV, et al. Cancer risk in 680,000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians. BMJ. 2013;346:f2360. PubMed PMID: 23694687.
Pearce MS, Salotti JA, et al. Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet. 2012;380(9840):499-505. PubMed PMID: 22681860.
Day RM, Barshishat-Kupper M, et al. Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation. Journal of radiation research. 2008;49(4):361-72. PubMed PMID: 18434686.
Ha CT, Li XH, et al. Genistein nanoparticles protect mouse hematopoietic system and prevent proinflammatory factors after gamma irradiation. Radiation research. 2013;180(3):316-25. PubMed PMID: 23952576.
Background and Mechanism of Action
Chen FP, Chien MH. Phytoestrogens induce differential effects on both normal and malignant human breast cells in vitro. Climacteric : the journal of the International Menopause Society. 2014:1-26. PubMed PMID: 24978400.
Li J, Li J, et al. Genistein suppresses tumor necrosis factor alpha-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor kappaB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells. Drug design, development and therapy. 2014;8:315-23. PubMed PMID: 24669186.
Liu GD, Xia L, et al. Genistein alleviates radiation-induced pneumonitis by depressing Ape1/Ref-1 expression to down-regulate inflammatory cytokines. Cell biochemistry and biophysics. 2014;69(3):725-33. PubMed PMID: 24659138.
Liu X, Sun C, et al. Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region. Oncotarget. 2016. PubMed PMID: 27029077.