Relevant Publications

Oncology

Abernathy LM, Fountain MD, et al. Soy Isoflavones Promote Radioprotection of Normal Lung Tissue by Inhibition of Radiation-Induced Activation of Macrophages and Neutrophils. Journal of thoracic oncology. 2015;10(12):1703-12. PubMed PMID: 26709479.

Ahmad IU, Forman JD, et al. Soy isoflavones in conjunction with radiation therapy in patients with prostate cancer. Nutrition and cancer. 2010;62(7):996-1000. PubMed PMID: 20924975.

Fountain MD, Abernathy LM, et al. Radiation-Induced Esophagitis is Mitigated by Soy Isoflavones. Frontiers in oncology. 2015;5:238. PubMed PMID: 26557504.

Gallo D, Zannoni GF, et al. Soy phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice. The Journal of nutrition. 2008;138(7):1360-4. PubMed PMID: 18567761.

Hillman GG, Singh-Gupta V, et al. Differential effect of soy isoflavones in enhancing high intensity radiotherapy and protecting lung tissue in a pre-clinical model of lung carcinoma. Radiotherapy and oncology. 2013;109(1):117-25. PubMed PMID: 24021346.

Raffoul JJ, Banerjee S, et al. Soy isoflavones enhance radiotherapy in a metastatic prostate cancer model. International journal of cancer. 2007;120(11):2491-8. PubMed PMID: 17304503.

Russo M, Russo GL, et al. Understanding genistein in cancer: The "good" and the "bad" effects: A review. Food chemistry. 2016;196:589-600. PubMed PMID: 26593532.

Medical Imaging

Mathews JD, Forsythe AV, et al. Cancer risk in 680,000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians. BMJ. 2013;346:f2360. PubMed PMID: 23694687.

Nguyen PK, Lee WH, et al. Assessment of the Radiation Effects of Cardiac CT Angiography Using Protein and Genetic Biomarkers. JACC Cardiovasc Imaging. 2015;8(8):873-84. PubMed PMID: 26210695.

Pearce MS, Salotti JA, et al. Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet. 2012;380(9840):499-505. PubMed PMID: 22681860. 

Medical Countermeasures

Davis TA, Mungunsukh O, et al. Genistein induces radioprotection by hematopoietic stem cell quiescence. International journal of radiation biology. 2008;84(9):713-26. PubMed PMID: 18821385.

Day RM, Barshishat-Kupper M, et al. Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation. Journal of radiation research. 2008;49(4):361-72. PubMed PMID: 18434686.

Ha CT, Li XH, et al. Genistein nanoparticles protect mouse hematopoietic system and prevent proinflammatory factors after gamma irradiation. Radiation research. 2013;180(3):316-25. PubMed PMID: 23952576.

Singh VK, Grace MB, et al. Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice. International immunopharmacology. 2009;9(12):1401-10. PubMed PMID: 19716438.

Background and Mechanism of Action

Chen FP, Chien MH. Phytoestrogens induce differential effects on both normal and malignant human breast cells in vitro. Climacteric : the journal of the International Menopause Society. 2014:1-26. PubMed PMID: 24978400.

Li J, Li J, et al. Genistein suppresses tumor necrosis factor alpha-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor kappaB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells. Drug design, development and therapy. 2014;8:315-23. PubMed PMID: 24669186.

Liu GD, Xia L, et al. Genistein alleviates radiation-induced pneumonitis by depressing Ape1/Ref-1 expression to down-regulate inflammatory cytokines. Cell biochemistry and biophysics. 2014;69(3):725-33. PubMed PMID: 24659138.

Liu X, Sun C, et al. Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region. Oncotarget. 2016. PubMed PMID: 27029077.

Raffoul JJ, Wang Y, et al. Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. BMC cancer. 2006;6:107. PubMed PMID: 16640785.

Yang Z, Kulkarni K, et al. Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME. Anti-cancer agents in medicinal chemistry. 2012;12(10):1264-80. PubMed PMID: 22583407.