BIO300 - Mechanism of Action

BIO 300 contains a highly bioavailable form of genistein which has a variety of beneficial biological properties.  BIO 300’s biological activity is centered on four key responses to radiation exposure: (1) DNA damage repair, (2) Cell death or apoptosis, (3) Oxidative stress, and (4) Inflammation. Key molecular targets of BIO 300 mediating its efficacy include the PI3K/Akt and NF-κβ pathways. In addition, BIO 300 is also a weak phytoestrogen which affects cell cycle regulation, inflammatory response and DNA damage repair. This unique, multifaceted mechanism of action supports genistein’s distinct ability to radiosensitize or directly kill cancer cells, while it protects normal cells from radiation toxicities.