BIO 300 – A Unique, Highly Selective Radiation Modulator
BIO 300 is being developed as a radiation modulator for multiple indications and has been extensively studied as a potential cancer therapeutic and as a radioprotectant. It was the subject of a 15-year program of study by the Armed Forces Radiobiology Research Institute where its radioprotective effects were confirmed. The active ingredient in BIO 300 is a small molecule with limited solubility and poor oral bioavailability, which prevents absorption of therapeutic doses without proper formulations. Humanetics has developed a patented, stable nano-particle formulation that greatly improves oral bioactivity (see Pharmacokinetic Data).
BIO 300 has a variety of biological effects, which leads to its unique efficacy as a radiation modulator. These include effects on cell cycle regulation, oxidative stress and inflammation. (see Mechanism of Action).
BIO 300's unique, selective mechanism sensitizes tumor cells to radiation-induced killing, while protecting normal tissues. It is also directly cytotoxic to selected neoplastic cell types, without associated toxicities to normal cell function. BIO 300 is in a Phase I/II clinical trial in patients undergoing radiochemotherapy for non-small cell lung cancer. See more about this trial.